| Title: | DESIGN OF MULTIFUNCTIONAL MOLECULE FOR TREATMENT OF ACNE SYNTHESIS OF SKIN SOLUBLE BENZOPHENONE PEROXYESTERS |
| Author: | Arutyunyan, Sergey L. |
| Description: | Acne vulgaris is the most common skin disorder whose pathogenesis appears to be multifactorial. A synthetic scheme for a new multifunctional peroxyester compound for acne treatment was proposed and successfully completed. This compound (8) contains three parts which are expected to serve different functions. A tert-Bu perester moiety would serve as radical generating part for acne treatment. The benzophenone chromophore would photochemically control radical generation. Finally, the diethyleneglycol methyl ether part is expected to increase the skin affinity of the proposed molecule. Compound (8) shows characteristic absorption of the benzophenone chromophore with maxima at 348 and 256 nm. Combinatorial experiments were performed by reacting eight different alcohols with methyl 4-(4-bromomethylbenzoyl) benzoate (4) as the common substrate. |
| Bookmark: |
http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1126651865
http://hdl.handle.net/123456789/6647 |
| Date: | 2005 |
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